Guanine nucleotide transport

Across TCGA patient cohorts, RNA activity of the Guanine nucleotide transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCC4, RRNAD1, and FMO6P, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Guanine nucleotide transport activity versus ABCC4 in OV (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ABCC4 →	+1.053	+0.756	<.001	.002	1	5
OV	RRNAD1 →	-0.494	-0.675	<.001	.006	3	3
UCEC	FMO6P →	+0.987	+0.518	.007	.007	3	3
LSCC	RIN2 →	+0.481	+0.639	.001	.005	3	3
BRCA	ATP13A5 →	+1.564	+0.284	<.001	<.001	3	3
GBM	SRD5A1 →	+0.512	+0.635	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001408 vs ABCC4 — OV

Explore this scatter interactively →