Guanine nucleotide transport

Across TCGA cell cohorts, RNA activity of the Guanine nucleotide transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRBF2, LIME1, and GEMIN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NRBF2 grouped by Guanine nucleotide transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NRBF2 →	+0.546	+1.200	.007	<.001	3	4
SKIN	LIME1 →	-0.629	-1.250	<.001	<.001	3	4
CNS	GEMIN4 →	-0.516	-0.895	.001	.001	3	3
OESOPHAGUS	MAPK3 →	+0.699	+0.712	.008	.005	2	4
KIDNEY	TYK2 →	+0.546	+1.278	.006	.004	3	3
KIDNEY	QPCT →	-1.930	-1.116	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NRBF2 by Guanine nucleotide transport activity — BLOOD_Leukemia

Explore this box plot interactively →