Guanine nucleotide transport

Across TCGA cell cohorts, RNA activity of the Guanine nucleotide transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCK2, ZNF624, and HADH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Guanine nucleotide transport activity versus UCK2 in PANCREAS (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	UCK2 →	-0.774	-0.875	<.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF624 →	-0.564	-1.067	<.001	.004	3	4
LUNG_SCLC	HADH →	-1.461	-0.292	<.001	.003	3	4
OESOPHAGUS	ST6GALNAC2 →	+3.014	+1.522	<.001	.001	3	3
OESOPHAGUS	PKP1 →	+4.357	+1.303	<.001	<.001	3	3
BLOOD_Leukemia	RBBP9 →	-1.017	-0.466	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001408 vs UCK2 — PANCREAS

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