Formation of extrachromosomal circular DNA

Across TCGA patient cohorts, RNA activity of the Formation of extrachromosomal circular DNA pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRIP1, DNA2, and ZGRF1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Formation of extrachromosomal circular DNA activity versus BRIP1 in THYM (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	BRIP1 →	+1.468	+0.097	<.001	<.001	3	33
THYM	DNA2 →	+1.587	+0.105	<.001	<.001	3	33
THYM	ZGRF1 →	+1.171	+0.096	<.001	<.001	3	33
UVM	MTBP →	+0.984	+0.027	<.001	<.001	3	33
DLBC	ATAD5 →	+1.292	+0.081	<.001	<.001	3	33
THYM	CEP192 →	+1.184	+0.072	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001325 vs BRIP1 — THYM

Explore this scatter interactively →