RNA polymerase I preinitiation complex assembly

Across TCGA patient cohorts, RNA activity of the RNA polymerase I preinitiation complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DBN1_S337, DNMT3A, and ADNP_S921, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA polymerase I preinitiation complex assembly activity versus DBN1_S337 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DBN1_S337 →	+0.530	+0.044	.003	.001	3	6
GBM	DNMT3A →	+0.468	+0.067	<.001	<.001	3	6
LSCC	ADNP_S921 →	+0.602	+0.103	<.001	<.001	3	6
GBM	SF3B3 →	+0.260	+0.069	<.001	<.001	3	6
GBM	UBTF →	+0.282	+0.046	<.001	<.001	3	6
GBM	XRCC1 →	+0.264	+0.052	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001188 vs DBN1_S337 — BRCA

Explore this scatter interactively →