RNA polymerase I preinitiation complex assembly

Across TCGA patient cohorts, RNA activity of the RNA polymerase I preinitiation complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HELLS, MEF2C, and DTL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA polymerase I preinitiation complex assembly activity versus HELLS in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HELLS →	+0.740	+0.697	<.001	.001	3	6
GBM	MEF2C →	-0.510	-0.810	<.001	<.001	3	6
GBM	DTL →	+1.048	+0.624	<.001	.005	3	5
GBM	PHYHIP →	-0.985	-0.744	<.001	<.001	3	5
GBM	EZH2 →	+0.499	+0.533	.003	.003	3	5
GBM	KIF20A →	+0.989	+1.032	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001188 vs HELLS — GBM

Explore this scatter interactively →