RNA polymerase I preinitiation complex assembly

Across TCGA patient cohorts, RNA activity of the RNA polymerase I preinitiation complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMARCA4_S1631, SMARCA4_S1663, and SRRM2_S1483, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA polymerase I preinitiation complex assembly activity versus SMARCA4_S1631 in CCRCC (Pearson r = 0.82).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SMARCA4_S1631 →	+1.668	+2.610	<.001	<.001	2	7
CCRCC	SMARCA4_S1663 →	+1.668	+2.610	<.001	<.001	2	7
OV	SRRM2_S1483 →	+1.172	+0.473	<.001	<.001	3	6
BRCA	SMARCA4_S1452 →	+0.612	+1.147	<.001	<.001	3	6
BRCA	SMARCA4_S1484 →	+0.612	+1.147	<.001	<.001	3	6
GBM	SNRNP200 →	+0.195	+0.812	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001188 vs SMARCA4_S1631 — CCRCC

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