RNA polymerase I preinitiation complex assembly

Across TCGA cell cohorts, RNA activity of the RNA polymerase I preinitiation complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBI, COL5A1, and FHOD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TGFBI grouped by RNA polymerase I preinitiation complex assembly-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TGFBI →	-5.065	-1.194	<.001	.003	3	5
OVARY	COL5A1 →	-3.941	-1.570	<.001	<.001	3	4
BLOOD_Lymphoma	FHOD3 →	-3.464	-0.373	.002	.002	3	4
OVARY	STAT2 →	-0.923	-0.987	.005	.006	3	4
OVARY	SMARCA2 →	-1.718	-0.910	<.001	<.001	3	4
LUNG_NSCLC_LUAD	STS →	-0.873	-0.346	.007	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TGFBI by RNA polymerase I preinitiation complex assembly activity — OVARY

Explore this box plot interactively →