RNA polymerase I preinitiation complex assembly

Across TCGA cell cohorts, RNA activity of the RNA polymerase I preinitiation complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBP, TAF1B, and NUP43, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA polymerase I preinitiation complex assembly activity versus TBP in URINARY_TRACT (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TBP →	+0.811	+0.095	<.001	.003	3	19
LUNG_NSCLC_LUSC	TAF1B →	+1.042	+0.144	.001	<.001	3	18
BLOOD_Lymphoma	NUP43 →	+0.859	+0.082	.001	.002	3	18
OVARY	SCAF8 →	+0.838	+0.068	<.001	.001	3	17
BLOOD_Lymphoma	TCP1 →	+1.158	+0.107	<.001	<.001	3	17
PANCREAS	EXOSC2 →	+1.141	+0.104	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001188 vs TBP — URINARY_TRACT

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