RNA polymerase I preinitiation complex assembly

Across TCGA cell cohorts, RNA activity of the RNA polymerase I preinitiation complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED3, CHD4, and GTF3C4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA polymerase I preinitiation complex assembly activity versus TMED3 in OESOPHAGUS (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TMED3 →	-0.893	-0.212	.002	.005	2	7
BLOOD_Leukemia	CHD4 →	+0.421	+0.196	<.001	.005	3	6
BREAST	GTF3C4 →	+0.644	+0.287	.007	.001	3	5
BLOOD_Leukemia	SHQ1 →	+0.942	+0.188	.003	.009	3	5
BLOOD_Leukemia	SMARCC1 →	+0.892	+0.309	<.001	<.001	3	5
BREAST	VKORC1L1 →	+0.439	+0.167	.005	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001188 vs TMED3 — OESOPHAGUS

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