Response to acid chemical

Across TCGA patient cohorts, RNA activity of the Response to acid chemical pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS13B, ZBED6, and NID2, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to acid chemical activity versus VPS13B in UVM (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	VPS13B →	+1.320	+0.023	<.001	<.001	3	34
CHOL	ZBED6 →	+1.655	+0.038	<.001	<.001	3	34
THYM	NID2 →	+2.058	+0.031	<.001	<.001	3	34
THYM	NFAT5 →	+2.103	+0.040	<.001	<.001	3	33
SCLC	HIVEP2 →	+1.307	+0.125	<.001	<.001	3	33
DLBC	ELF2 →	+1.222	+0.030	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001101 vs VPS13B — UVM

Explore this scatter interactively →