Response to acid chemical

Across TCGA patient cohorts, RNA activity of the Response to acid chemical pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FLNA, PRKG1, and THBS2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to acid chemical activity versus FLNA in UCEC (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FLNA →	+0.573	+0.051	.004	.004	3	9
OV	PRKG1 →	+0.466	+0.030	.001	.001	3	9
COAD	THBS2 →	+1.205	+0.025	<.001	<.001	3	8
CCRCC	VCL →	+0.357	+0.024	.003	.003	3	8
COAD	RSU1 →	+0.306	+0.020	.008	<.001	2	9
GBM	COPZ2 →	+0.510	+0.035	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001101 vs FLNA — UCEC

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