Response to acid chemical

Across TCGA patient cohorts, RNA activity of the Response to acid chemical pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPE, DDX18, and INSYN2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to acid chemical activity versus SNRPE in HNSC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SNRPE →	-1.593	-0.286	<.001	.006	3	4
HNSC	DDX18 →	-0.723	-0.259	.001	<.001	3	4
OV	INSYN2B →	+0.326	+0.289	.008	.002	3	3
BRCA	EIF3L →	-0.596	-0.157	<.001	.001	3	3
HNSC	FBL →	-1.013	-0.216	.006	.004	3	3
CCRCC	NRP2 →	+0.730	+0.110	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001101 vs SNRPE — HNSC

Explore this scatter interactively →