Response to acid chemical

Across TCGA cell cohorts, RNA activity of the Response to acid chemical pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF16, HIGD2A, and KIF5A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF16 grouped by Response to acid chemical-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLF16 →	-0.737	-0.152	.002	.007	3	4
LUNG_NSCLC_LUAD	HIGD2A →	-0.758	-0.142	<.001	<.001	3	4
LUNG_SCLC	KIF5A →	-2.176	-0.198	.009	.003	3	4
BLOOD_Myeloma	DIRAS1 →	-1.622	-0.259	<.001	.005	3	4
SOFT_TISSUE	ARFGEF3 →	+2.101	+0.218	<.001	.002	3	4
LIVER	RGS19 →	+0.956	+0.328	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF16 by Response to acid chemical activity — LARGE_INTESTINE

Explore this box plot interactively →