Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

Across TCGA patient cohorts, RNA activity of the Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLA1, RNY1P13, and NUP155, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery activity versus POLA1 in LSCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POLA1 →	+0.464	+0.202	.007	.004	3	5
HNSC	RNY1P13 →	+0.619	+0.432	.005	.003	3	5
LSCC	NUP155 →	+0.626	+0.262	<.001	<.001	3	5
LSCC	NIPBL →	+0.410	+0.204	<.001	.002	3	5
LSCC	RALGAPB →	+0.350	+0.161	<.001	.008	3	5
COAD	BRCA1P1 →	+1.026	+0.757	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000972 vs POLA1 — LSCC

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