Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

Across TCGA cell cohorts, RNA activity of the Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HPRT1, MAFK, and ENO2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HPRT1 grouped by Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HPRT1 →	-0.770	-0.141	.003	.002	3	4
BONE	MAFK →	+1.289	+0.381	.003	<.001	3	3
KIDNEY	ENO2 →	+1.644	+0.385	<.001	<.001	3	3
KIDNEY	FASTKD3 →	-0.755	-0.345	<.001	.002	3	3
KIDNEY	AK6 →	+1.051	+0.568	<.001	.001	3	3
PANCREAS	IFNE →	-2.256	-0.309	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HPRT1 by Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery activity — BREAST

Explore this box plot interactively →