Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

Across TCGA cell cohorts, RNA activity of the Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF14, PARP1, and NUP133, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery activity versus KIF14 in SOFT_TISSUE (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KIF14 →	+1.410	+0.153	<.001	<.001	3	19
BLOOD_Lymphoma	PARP1 →	+1.434	+0.107	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	NUP133 →	+1.031	+0.165	<.001	<.001	3	19
LUNG_NSCLC_LUSC	SPRTN →	+0.776	+0.145	<.001	<.001	3	18
LARGE_INTESTINE	NUP155 →	+1.031	+0.140	<.001	<.001	3	18
BLOOD_Lymphoma	MSH6 →	+1.286	+0.082	.002	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000972 vs KIF14 — SOFT_TISSUE

Explore this scatter interactively →