Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

Across TCGA cell cohorts, RNA activity of the Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM230, ZBTB7A, and DLK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery activity versus TMEM230 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TMEM230 →	+0.790	+0.166	.002	.007	3	5
STOMACH	ZBTB7A →	-1.090	-0.372	.009	.001	3	5
OESOPHAGUS	DLK2 →	+2.320	+0.258	.001	.005	3	4
OESOPHAGUS	PTHLH →	+4.203	+0.317	<.001	<.001	3	4
BLOOD_Myeloma	CDH24 →	+1.270	+0.173	.002	.002	3	4
OVARY	ANG →	-1.364	-0.233	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000972 vs TMEM230 — UPPER_AERODIGESTIVE_TRACT

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