rRNA 5'-end processing

Across TCGA cell cohorts, RNA activity of the rRNA 5'-end processing pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBL3, TMEM74, and COMMD7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBL3 grouped by rRNA 5'-end processing-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TBL3 →	-0.425	-0.144	<.001	<.001	3	4
LUNG_NSCLC_LUSC	TMEM74 →	+0.216	+0.142	.007	.009	3	3
LUNG_NSCLC_LUAD	COMMD7 →	+0.140	+0.104	.002	.009	3	3
LUNG_NSCLC_LUAD	LRRC8C →	+0.332	+0.118	.004	.003	3	3
OESOPHAGUS	AHSA2P →	+0.119	+0.127	.005	.002	3	3
LUNG_SCLC	MIOX →	-0.170	-0.135	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBL3 by rRNA 5'-end processing activity — LUNG_SCLC

Explore this box plot interactively →