rRNA 5'-end processing

Across TCGA cell cohorts, RNA activity of the rRNA 5'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UTP20, CCDC86, and NOP2, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA 5'-end processing activity versus UTP20 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	UTP20 →	+1.388	+0.157	<.001	<.001	3	20
LIVER	CCDC86 →	+1.594	+0.176	<.001	<.001	3	19
LIVER	NOP2 →	+1.221	+0.183	<.001	<.001	3	19
BLOOD_Lymphoma	NCL →	+0.948	+0.093	<.001	<.001	3	19
STOMACH	NUP153 →	+0.966	+0.094	.002	.004	3	19
PANCREAS	GNL3L →	+1.420	+0.139	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000967 vs UTP20 — UPPER_AERODIGESTIVE_TRACT

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