rRNA 5'-end processing

Across TCGA cell cohorts, RNA activity of the rRNA 5'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAGK, COPA, and RTL8A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA 5'-end processing activity versus NAGK in BREAST (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NAGK →	-0.828	-1.248	.001	<.001	3	7
LUNG_NSCLC_LUSC	COPA →	-0.765	-1.976	<.001	<.001	3	6
LARGE_INTESTINE	RTL8A →	-2.704	-0.913	<.001	.005	3	6
LIVER	RAB8B →	-1.314	-1.867	.004	<.001	3	5
LUNG_SCLC	CDKN2C →	-1.293	-1.143	<.001	<.001	3	5
LUNG_SCLC	PUS1 →	+0.736	+1.106	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000967 vs NAGK — BREAST

Explore this scatter interactively →