RNA 5'-end processing

Across TCGA patient cohorts, RNA activity of the RNA 5'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA3, PLK1, and ESPL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA 5'-end processing activity versus CDCA3 in BRCA (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDCA3 →	+0.677	+0.219	<.001	<.001	3	7
BRCA	PLK1 →	+0.704	+0.227	.001	.002	3	7
BRCA	ESPL1 →	+0.872	+0.291	<.001	<.001	3	6
BRCA	FANCA →	+0.920	+0.326	<.001	<.001	2	7
BRCA	TCOF1 →	+0.439	+0.200	.001	.007	3	5
LSCC	TWNK →	+0.561	+0.173	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000966 vs CDCA3 — BRCA

Explore this scatter interactively →