RNA 5'-end processing

Across TCGA cell cohorts, RNA activity of the RNA 5'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMEPA1, HOXA6, and CD44, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA 5'-end processing activity versus PMEPA1 in LIVER (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PMEPA1 →	-5.781	-0.165	<.001	.002	3	4
BLOOD_Myeloma	HOXA6 →	+1.597	+0.133	.007	.008	3	4
BLOOD_Myeloma	CD44 →	-4.689	-0.116	.002	.007	3	4
PANCREAS	SLC35A3 →	+1.012	+0.250	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZBTB26 →	+0.744	+0.189	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	USP33 →	+0.867	+0.189	.005	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000966 vs PMEPA1 — LIVER

Explore this scatter interactively →