Mitochondrial RNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the Mitochondrial RNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILK, ACTR3C, and JCAD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ILK grouped by Mitochondrial RNA 3'-end processing-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ILK →	-1.081	-0.225	.001	.006	3	6
SKIN	ACTR3C →	-1.354	-0.169	.007	.006	3	5
LUNG_NSCLC_LUAD	JCAD →	-1.826	-0.178	<.001	<.001	3	5
STOMACH	ADRB2 →	-1.537	-0.205	.004	.002	2	6
LUNG_NSCLC_LUAD	SPATS2L →	-1.433	-0.179	<.001	.002	3	5
BREAST	KIRREL1 →	-2.949	-0.255	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ILK by Mitochondrial RNA 3'-end processing activity — STOMACH

Explore this box plot interactively →