Mitochondrial RNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the Mitochondrial RNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFXN4, NOP16, and MED15, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA 3'-end processing activity versus SFXN4 in LARGE_INTESTINE (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SFXN4 →	+0.825	+0.203	.001	.001	3	7
OESOPHAGUS	NOP16 →	+1.081	+0.180	.006	.007	3	6
BREAST	MED15 →	-0.817	-0.164	.001	.003	3	6
BLOOD_Lymphoma	NIP7 →	+0.707	+0.147	.008	.003	3	6
PANCREAS	CHCHD4 →	+1.305	+0.261	.001	<.001	3	6
PANCREAS	RRP9 →	+1.227	+0.223	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000965 vs SFXN4 — LARGE_INTESTINE

Explore this scatter interactively →