Mitochondrial RNA processing

Across TCGA patient cohorts, RNA activity of the Mitochondrial RNA processing pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATXN1, OMD, and GASK1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA processing activity versus ATXN1 in OV (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ATXN1 →	-0.499	-0.137	.002	.002	3	5
OV	OMD →	-1.922	-0.186	<.001	<.001	3	5
OV	GASK1B →	-0.703	-0.126	<.001	<.001	3	5
OV	TCF4 →	-0.748	-0.172	<.001	<.001	3	5
PDAC	NREP →	-0.395	-0.168	<.001	.003	3	4
BRCA	SPRED1 →	-0.639	-0.258	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000963 vs ATXN1 — OV

Explore this scatter interactively →