Mitochondrial RNA processing

Across TCGA patient cohorts, RNA activity of the Mitochondrial RNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TFB2M, FASTKD2, and CDK5RAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA processing activity versus TFB2M in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFB2M →	+0.537	+0.277	<.001	<.001	3	5
UCEC	FASTKD2 →	+0.358	+0.280	<.001	<.001	3	5
GBM	CDK5RAP1 →	+0.460	+0.150	<.001	<.001	3	5
OV	TBL3 →	+0.265	+0.149	.001	<.001	3	4
OV	WDR36 →	+0.274	+0.140	.006	<.001	2	5
PDAC	FASTKD5 →	+0.433	+0.238	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000963 vs TFB2M — UCEC

Explore this scatter interactively →