Mitochondrial RNA processing

Across TCGA cell cohorts, RNA activity of the Mitochondrial RNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM32A, MT-ND1, and MERTK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA processing activity versus FAM32A in BREAST (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FAM32A →	-0.654	-0.125	<.001	.002	3	5
BLOOD_Lymphoma	MT-ND1 →	+0.849	+0.106	.002	.003	3	5
OESOPHAGUS	MERTK →	+1.113	+0.073	.004	.006	3	4
BLOOD_Lymphoma	HMGXB4 →	-0.694	-0.136	.006	.004	3	4
KIDNEY	MIDN →	-1.236	-0.158	.006	.003	3	4
LIVER	TNPO2 →	-0.718	-0.165	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000963 vs FAM32A — BREAST

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