Regulation of mitochondrial RNA catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial RNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOP58, PNPT1, and WDR43, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial RNA catabolic process activity versus NOP58 in UVM (Pearson r = 0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	NOP58 →	+2.012	+0.105	<.001	<.001	3	34
UVM	PNPT1 →	+1.784	+0.112	<.001	<.001	3	33
UVM	WDR43 →	+1.782	+0.099	<.001	<.001	3	33
DLBC	DDX21 →	+1.800	+0.061	<.001	<.001	3	33
UVM	NOC3L →	+1.611	+0.106	<.001	<.001	3	33
UVM	CCAR1 →	+2.002	+0.106	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000960 vs NOP58 — UVM

Explore this scatter interactively →