Regulation of mitochondrial RNA catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial RNA catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUPV3L1, DDX50, and ATAD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial RNA catabolic process activity versus SUPV3L1 in LUAD (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SUPV3L1 →	+0.408	+0.043	<.001	<.001	3	7
HNSC	DDX50 →	+0.303	+0.073	<.001	.001	3	7
LUAD	ATAD1 →	+0.302	+0.043	.003	<.001	3	6
LUAD	BRIX1 →	+0.351	+0.034	<.001	<.001	3	6
BRCA	CCDC6_S52 →	+0.682	+0.038	.001	.002	3	6
BRCA	CDK1 →	+0.769	+0.044	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000960 vs SUPV3L1 — LUAD

Explore this scatter interactively →