Regulation of mitochondrial RNA catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial RNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFATC2, RHOJ, and CCNB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial RNA catabolic process activity versus NFATC2 in LUAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NFATC2 →	-0.514	-0.202	.002	<.001	3	6
OV	RHOJ →	-0.704	-0.211	.002	<.001	3	5
UCEC	CCNB1 →	+0.960	+0.122	<.001	.001	3	5
UCEC	MDH2 →	+0.707	+0.130	<.001	.002	3	5
UCEC	PLCL2 →	-1.054	-0.158	<.001	.001	3	5
LSCC	SUPV3L1 →	+0.526	+0.175	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000960 vs NFATC2 — LUAD

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