Regulation of mitochondrial RNA catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial RNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TARS1, CPEB2, and BEND3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial RNA catabolic process activity versus TARS1 in OVARY (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TARS1 →	+0.706	+0.123	<.001	<.001	3	5
URINARY_TRACT	CPEB2 →	-1.176	-0.182	.002	.002	3	4
URINARY_TRACT	BEND3 →	+0.656	+0.183	.001	.001	3	4
SOFT_TISSUE	SMYD5 →	+0.582	+0.158	<.001	.003	2	5
KIDNEY	MCCC2 →	+1.317	+0.554	.004	.004	3	4
BLOOD_Lymphoma	KCND1 →	+1.028	+0.106	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000960 vs TARS1 — OVARY

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