Mitochondrial RNA metabolic process

Across TCGA patient cohorts, RNA activity of the Mitochondrial RNA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZMYM3, RPRD2, and VPS13C_S737, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA metabolic process activity versus ZMYM3 in HNSC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZMYM3 →	+0.272	+0.069	.002	.005	3	7
LSCC	RPRD2 →	+0.289	+0.053	<.001	<.001	3	6
OV	VPS13C_S737 →	-0.790	-0.029	.002	<.001	3	6
HNSC	TNKS1BP1_S601 →	-0.569	-0.059	<.001	.006	3	6
LSCC	BRD8 →	+0.253	+0.051	<.001	<.001	3	6
LUAD	PARP1 →	+0.427	+0.044	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000959 vs ZMYM3 — HNSC

Explore this scatter interactively →