Mitochondrial RNA metabolic process

Across TCGA patient cohorts, RNA activity of the Mitochondrial RNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSO, EME1, and MARS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA metabolic process activity versus CTSO in LUAD (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CTSO →	-0.510	-0.163	<.001	<.001	3	5
PDAC	EME1 →	+0.448	+0.126	<.001	.005	3	5
HNSC	MARS2 →	+0.708	+0.204	.003	.006	2	5
UCEC	FAM83D →	+1.051	+0.274	<.001	<.001	3	4
LSCC	EEF1D →	+0.449	+0.235	.002	.006	3	4
LUAD	HROB →	+0.747	+0.153	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000959 vs CTSO — LUAD

Explore this scatter interactively →