Mitochondrial RNA metabolic process

Across TCGA cell cohorts, RNA activity of the Mitochondrial RNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APAF1, NRM, and JAK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA metabolic process activity versus APAF1 in OVARY (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	APAF1 →	-0.754	-0.113	.002	.002	3	6
LUNG_SCLC	NRM →	-1.093	-0.208	<.001	<.001	3	5
LUNG_SCLC	JAK2 →	-0.556	-0.137	.007	.009	3	5
URINARY_TRACT	GLIPR1 →	-2.530	-0.231	.002	.004	2	6
OVARY	P4HA2 →	-0.916	-0.144	.008	.004	3	5
CNS	SGCB →	-0.989	-0.169	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000959 vs APAF1 — OVARY

Explore this scatter interactively →