Mitochondrial RNA catabolic process

Across TCGA cell cohorts, RNA activity of the Mitochondrial RNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are REXO2, RPL14, and DFFA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA catabolic process activity versus REXO2 in BREAST (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	REXO2 →	+1.399	+0.218	<.001	<.001	3	8
BLOOD_Myeloma	RPL14 →	+0.693	+0.241	.007	.003	3	7
OESOPHAGUS	DFFA →	+1.057	+0.168	.003	<.001	2	7
BLOOD_Myeloma	CEP164 →	+1.063	+0.205	.004	.006	2	7
OESOPHAGUS	ZPR1 →	+0.967	+0.137	.004	.006	2	7
BLOOD_Myeloma	VPS11 →	+0.847	+0.276	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000957 vs REXO2 — BREAST

Explore this scatter interactively →