Nuclear-transcribed mRNA catabolic process

Across TCGA patient cohorts, RNA activity of the Nuclear-transcribed mRNA catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSIP1, ARID4B, and SLC16A3_S436, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear-transcribed mRNA catabolic process activity versus PSIP1 in HNSC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PSIP1 →	+0.548	+0.061	<.001	.002	3	6
HNSC	ARID4B →	+0.221	+0.074	<.001	<.001	3	6
CCRCC	SLC16A3_S436 →	-0.855	-0.028	<.001	<.001	3	6
COAD	DHX32 →	-0.398	-0.038	<.001	<.001	3	6
CCRCC	RPL5 →	-0.192	-0.025	.003	.007	3	6
HNSC	GATAD2B →	+0.368	+0.079	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000956 vs PSIP1 — HNSC

Explore this scatter interactively →