Nuclear-transcribed mRNA catabolic process

Across TCGA patient cohorts, RNA activity of the Nuclear-transcribed mRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKDCC, FAM167B, and INKA1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear-transcribed mRNA catabolic process activity versus PKDCC in OV (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PKDCC →	-2.012	-0.200	.002	.004	3	2
OV	FAM167B →	-1.044	-0.199	.009	.004	3	2
OV	INKA1 →	-1.348	-0.199	.006	.004	3	2
OV	RNU6-199P →	-1.226	-0.209	<.001	.008	3	2
OV	FHL1 →	-2.037	-0.199	<.001	.004	3	2
OV	MC1R →	-0.934	-0.199	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000956 vs PKDCC — OV

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