Nuclear-transcribed mRNA catabolic process

Across TCGA cell cohorts, RNA activity of the Nuclear-transcribed mRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH9A1, ATP8B3, and MICALL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALDH9A1 grouped by Nuclear-transcribed mRNA catabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ALDH9A1 →	-0.639	-0.259	.002	<.001	3	5
BREAST	ATP8B3 →	+0.971	+0.081	<.001	.007	3	5
LUNG_SCLC	MICALL1 →	+1.312	+0.145	.004	.003	3	4
LUNG_NSCLC_LUAD	KIF1A →	-1.716	-0.117	.006	.005	3	4
OVARY	KCNJ11 →	-0.892	-0.129	<.001	.007	3	4
BLOOD_Myeloma	MMAB →	-1.372	-0.190	.004	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALDH9A1 by Nuclear-transcribed mRNA catabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →