Nuclear-transcribed mRNA catabolic process

Across TCGA cell cohorts, RNA activity of the Nuclear-transcribed mRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM216A, TRNT1, and SF3A3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear-transcribed mRNA catabolic process activity versus FAM216A in PANCREAS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FAM216A →	+1.297	+0.170	.002	.009	3	7
SKIN	TRNT1 →	+0.809	+0.215	<.001	<.001	3	7
BREAST	SF3A3 →	+0.610	+0.212	<.001	<.001	3	6
LIVER	MB →	-2.116	-0.247	<.001	.004	3	6
SKIN	TEX10 →	+0.554	+0.289	.004	<.001	3	6
LUNG_NSCLC_LUAD	B4GALT4 →	-1.214	-0.235	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000956 vs FAM216A — PANCREAS

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