Cytokinesis

Across TCGA cell cohorts, RNA activity of the Cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIN52, C17orf80, and ZFP37, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LIN52 grouped by Cytokinesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LIN52 →	-0.863	-0.248	<.001	.008	3	5
CNS	C17orf80 →	-0.412	-0.226	.009	<.001	3	4
LUNG_NSCLC_LUSC	ZFP37 →	-0.901	-0.241	.003	.001	3	4
SKIN	HARS1 →	-0.364	-0.146	.008	<.001	3	4
URINARY_TRACT	CLDN16 →	+1.330	+0.246	.007	<.001	3	4
OESOPHAGUS	UBE2O →	-0.565	-0.188	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LIN52 by Cytokinesis activity — STOMACH

Explore this box plot interactively →