Cytokinesis

Across TCGA cell cohorts, RNA activity of the Cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WBP4, PRKCA, and IQANK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytokinesis activity versus WBP4 in OESOPHAGUS (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	WBP4 →	+0.507	+0.167	.003	.005	3	6
URINARY_TRACT	PRKCA →	+1.944	+0.383	.009	.002	3	5
BLOOD_Leukemia	IQANK1 →	-0.909	-0.210	<.001	<.001	3	5
BLOOD_Leukemia	DNMBP →	+1.253	+0.189	<.001	<.001	3	5
STOMACH	CCDC32 →	+0.736	+0.243	<.001	<.001	3	5
BLOOD_Leukemia	SMG6 →	+0.928	+0.211	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000910 vs WBP4 — OESOPHAGUS

Explore this scatter interactively →