Sister chromatid segregation

Across TCGA cell cohorts, RNA activity of the Sister chromatid segregation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RECQL4, PKP4, and C11orf54, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RECQL4 grouped by Sister chromatid segregation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RECQL4 →	-0.770	-0.211	.004	.005	3	5
LUNG_NSCLC_LUSC	PKP4 →	-0.652	-0.130	.002	.006	3	5
LUNG_NSCLC_LUSC	C11orf54 →	-0.845	-0.135	.009	<.001	3	5
SOFT_TISSUE	MRPS15 →	-0.634	-0.192	.006	.002	3	5
URINARY_TRACT	UBE2S →	-2.143	-0.366	.005	.004	3	4
URINARY_TRACT	MTMR10 →	-1.089	-0.256	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RECQL4 by Sister chromatid segregation activity — URINARY_TRACT

Explore this box plot interactively →