Sister chromatid segregation

Across TCGA cell cohorts, RNA activity of the Sister chromatid segregation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILF3, UHRF1, and MCM10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sister chromatid segregation activity versus ILF3 in PANCREAS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ILF3 →	+0.747	+0.147	<.001	.004	3	6
BLOOD_Leukemia	UHRF1 →	+1.749	+0.157	<.001	<.001	3	5
PANCREAS	MCM10 →	+1.305	+0.203	.009	.006	3	5
BLOOD_Leukemia	SMC2 →	+1.265	+0.195	<.001	<.001	3	5
PANCREAS	ZNF367 →	+1.357	+0.286	.001	<.001	3	5
BLOOD_Lymphoma	SAC3D1 →	+0.677	+0.133	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000819 vs ILF3 — PANCREAS

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