DNA synthesis involved in DNA repair

Across TCGA patient cohorts, RNA activity of the DNA synthesis involved in DNA repair pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KNTC1, ARHGAP11A, and MYBL2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA synthesis involved in DNA repair activity versus KNTC1 in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KNTC1 →	+0.684	+0.467	<.001	<.001	3	8
BRCA	ARHGAP11A →	+0.995	+0.941	<.001	<.001	3	8
BRCA	MYBL2 →	+1.257	+0.487	<.001	<.001	3	7
LSCC	ASF1B →	+0.932	+0.928	<.001	<.001	3	7
BRCA	SGO1 →	+0.867	+0.848	<.001	<.001	3	7
UCEC	SGO2 →	+0.628	+0.767	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000731 vs KNTC1 — GBM

Explore this scatter interactively →