DNA synthesis involved in DNA repair

Across TCGA cell cohorts, RNA activity of the DNA synthesis involved in DNA repair pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTR3B, TTLL12, and GGCT, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA synthesis involved in DNA repair activity versus ACTR3B in BONE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ACTR3B →	+1.446	+1.478	.001	<.001	3	7
LUNG_NSCLC_LUAD	TTLL12 →	+0.781	+0.850	<.001	.001	3	7
BLOOD_Myeloma	GGCT →	+1.154	+1.517	.007	<.001	3	5
CNS	RSL1D1 →	+0.598	+0.682	.005	.001	2	6
OESOPHAGUS	FEZ1 →	-2.405	-0.986	.001	.004	3	5
OESOPHAGUS	CDT1 →	+0.978	+0.899	.007	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000731 vs ACTR3B — BONE

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