DNA double-strand break processing

Across TCGA cell cohorts, RNA activity of the DNA double-strand break processing pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPE, DSCC1, and KRT17, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA double-strand break processing activity versus RPE in OESOPHAGUS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RPE →	+1.007	+1.277	.003	.007	2	6
PANCREAS	DSCC1 →	+1.030	+1.037	.003	.007	3	5
LIVER	KRT17 →	-3.421	-1.795	.009	<.001	3	4
LIVER	PRPF40A →	+0.454	+1.498	.003	.002	3	4
LIVER	MAK16 →	+1.132	+1.506	<.001	<.001	3	4
PANCREAS	C12orf73 →	+0.570	+1.284	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000729 vs RPE — OESOPHAGUS

Explore this scatter interactively →