DNA double-strand break processing

Across TCGA cell cohorts, RNA activity of the DNA double-strand break processing pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MRE11, RAD50, and PSMA6, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA double-strand break processing activity versus MRE11 in PANCREAS (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MRE11 →	+1.318	+1.700	.001	<.001	3	18
LARGE_INTESTINE	RAD50 →	+1.119	+0.686	<.001	.006	3	18
URINARY_TRACT	PSMA6 →	+1.933	+2.344	<.001	<.001	3	14
URINARY_TRACT	NUTF2 →	+3.690	+2.040	<.001	<.001	3	14
URINARY_TRACT	YWHAB →	+2.923	+2.238	<.001	<.001	3	13
URINARY_TRACT	STIP1 →	+1.911	+1.576	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000729 vs MRE11 — PANCREAS

Explore this scatter interactively →