Double-strand break repair via break-induced replication

Across TCGA patient cohorts, RNA activity of the Double-strand break repair via break-induced replication pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN3, CENPI, and MCM4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via break-induced replication activity versus CDKN3 in BRCA (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDKN3 →	+0.822	+0.265	<.001	<.001	3	9
UCEC	CENPI →	+0.991	+0.282	<.001	<.001	3	9
OV	MCM4 →	+0.852	+0.260	<.001	<.001	3	9
LSCC	RFC5 →	+0.712	+0.258	<.001	<.001	3	9
UCEC	TIMELESS →	+0.794	+0.164	<.001	.001	3	9
BRCA	FBXO5 →	+0.674	+0.311	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000727 vs CDKN3 — BRCA

Explore this scatter interactively →