Double-strand break repair via break-induced replication

Across TCGA cell cohorts, RNA activity of the Double-strand break repair via break-induced replication pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS2, SPC25, and ORC6, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via break-induced replication activity versus GINS2 in STOMACH (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GINS2 →	+1.825	+0.235	<.001	<.001	3	20
BLOOD_Myeloma	SPC25 →	+1.592	+0.141	.002	.001	3	20
OESOPHAGUS	ORC6 →	+1.461	+0.247	.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	MCM6 →	+1.348	+0.174	<.001	<.001	3	20
BLOOD_Myeloma	SPAG5 →	+1.477	+0.180	.001	<.001	3	20
BLOOD_Myeloma	MCM2 →	+1.601	+0.173	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000727 vs GINS2 — STOMACH

Explore this scatter interactively →